Hypertrophic cardiomyopathy (HCM) has been defined morphologically by unexplained hypertrophy in the absence of haemodynamic stress, and at the histological level by myocyte disarray, fibrosis, and abnormalities of the intramyocardial small vessels.1 HCM is a monogenic cardiac disease with an autosomal dominant pattern of heritability and different penetrance, with a prevalence in the general population of 1/500.2 Mutations in 11 genes of contractile sarcomeric proteins have been shown to pro… Through a distal port on the balloon-tipped catheter,1-3 mL of ethanol is injected into the septal artery resulting in a controlled myocardial infarction. The main pathophysiology behind is that every organ is in homeostasis with physiological stress. Cardiomyopathy: Pathophysiology and Assessment RobertoMLang,MD Circ J 2004; 68: 77-81 Japanese word for octopus catcher Tako-Tsubo Cardiomyopathy Broken Heart Syndrome Apical Balooning 1. Clipping is a handy way to collect important slides you want to go back to later. Or use it to find and download high-quality how-to PowerPoint ppt presentations with illustrated or animated slides that will teach you how to do something new, also for free. Sudden cardiac death due to HCM-related causes is most prevalent in young African-American male athletes. Colors correspond to the Class of Recommendation Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. Luis Fuentes V, Wilkie L J (2017) Asymptomative hypertrophic cardiomyopathy: Diagnosis and therapy. Spirito, P. et al. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Vet Clin North Am Small Anim Pract 47 (5), 1041-1054 PubMed . Long-term Hypertension B. Aortic Stenosis C. Myocardial Ischemia D. Familial and Genetic, Hypertrophic Cardiomyopathy (HCM) Therapeutics Market Analysis by Demand, Trend, Revenue, Market Segment & Forecast to 2023. Hypertrophic cardiomyopathy (HCM) is a condition in which the heart becomes thickened without an obvious cause. Hypertrophic Cardiomyopathy. Hypertrophic cardiomyopathy (HCM) is a genetic disorder of cardiac myocytes that is characterized by cardiac hypertrophy, unexplained by the loading conditions; a nondilated left ventricle; and a normal or increased ejection fraction. Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder, with an autosomal dominant mechanism of inheritance. ... - Cardiomyopathy in neonates and children Dr Rajesh Kumar MD (PGI), DM (Neonatology) PGI, Chandigarh, India Rani Children Hospital, Ranchi Some cardiomyopathies are ... Clinical sensitivity of molecular genetic testing in hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy (HCM) has been defined morphologically by unexplained hypertrophy in the absence of haemodynamic stress, and at the histological level by myocyte disarray, fibrosis, and abnormalities of the intramyocardial small vessels. Long-term athletic training can produce “athlete’s heart” = increased LV diastolic cavity dimensions/wall thickness/mass. The mitral valve can also be affected and is unable to close properly. Ommen, SR et al. Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. Hogan DF, Fox P R, Jacob K et al (2015) Secondary prevention of cardiogenic arterial thromboembolism in the cat: The double-blind, randomized, positive-controlled feline arterial thromboembolism; clopidogrel vs. aspirin trial (FAT CAT). TM, 54, WAS ADMITTED to the ED after a syncopal episode that resulted in a head injury. HYPERTROPHIC. Over the years, classification of this condition has been updated by the rapid advancement of genetic, imaging, and clinical investigation. It is commonly asymmetrical with the most severe hypertrophy involving the basal interventricular septum. Sequencing of the Hypertrophic Cardiomyopathy (HCM) genes using an automated high throughput strategy, - Sequencing of the Hypertrophic Cardiomyopathy (HCM) genes using an automated high throughput strategy Aisha Ansari Edinburgh Molecular Genetics. Increased voltages c/w left ventricular hypertrophy Repolarization changes Q waves = not ischemia – reflect anterior septal thickness, Decreased projection of basal septum into the LVOT, Gold standard for pts w/ drug-refractory HCM Resect a small portion of myocardium from septum – enlarges LVOT and relieves obstruction; also causes concomitant mitral regurg to disappear Operative mortality: <1% Complications rare (heart block, VSD, aortic regurg). Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. This results in the heart being less able to pump blood effectively and also may cause electrical conduction problems.. People who have HCM may have a range of symptoms. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. - ... Day S, Rehm HL, Baxter S. Use and interpretation of genetic tests in cardiovascular genetics. Pathophysiology However, unlike the type above, the thickened area causes an obstruction that affects the flow of blood leaving the heart. The disease has complex symptomatology and potentially devastating consequences for … Change in stress leads to adaptations. Circulation. Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes which encode components of the contractile apparatus of the heart. Initial clinical and hemodynamic evaluation suggested cardiogenic shock in two cases, acute myocardial ischemia in two cases, and hypovolemia in one case. Cardiomyopathy may be classified as being Primary, in which there is no attributable cause, or Secondary, in which the cardiomyopathy is due to a specific cause, such as hypertension, coronary artery disease, congenital heart disease, heart valve disease, viral infections etc. Hypertrophic cardiomyopathy 1. It was first brought to attention by the British forensic pathologist Donald Teare in 1958 as a disease manifesting with symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle. Same group from Mayo Clinic Compared treatment effects of dual-chamber pacing versus septal myectomy Non-randomized prospective trial of 39 patients: 20  myectomy / 19  pacing Myectomy: greater reduction in LVOT gradients, larger improvements in NYHA class, exercise time, oxygen consumption. 1996;94:850-56. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. Cardiology Grand Rounds from the University of Texas Medical Branch Hypertrophic Cardiomyopathy: Presentation and Pathophysiology Marschall S. Runge, MD George A. Stouffer, MD * Richard G. Sheahan, MD Stamatios Lerakis, MD From the Division of Cardiology, Department of Medicine, The University of Texas Medical Branch, Galveston, Texas. 1,2 It has a prevalence of 1 in 500 within the general population, and is a known cause of sudden cardiac death. Dilated cardiomyopathy is the most common type of cardiomyopathy.Although most cases are idiopathic, a number of conditions (e.g., coronary artery disease, wet beriberi), infections … 1 It is typically inherited via autosomal dominant pattern with mutations in cardiac sarcomere protein genes. If you continue browsing the site, you agree to the use of cookies on this website. - Hypertrophic cardiomyopathy Frank and Mehta Non-Surgical Septal Ablation Echocardiographic still frames (systole) from the parasternal long-axis. Evaluation and Testing for HCM. Questions? Evaluation and Testing for HCM. - Cardiomyopathy (literally "heart muscle disease") is the measurable deterioration of the function of the myocardium (the heart muscle) for any reason usually leading to heart failure. CARDIOMYOPATHY BY: RICHARD KAMINSKI DESCRIPTION OF DISEASE • Hypertrophic cardiomyopathy (HCM) occurs if heart muscle cells enlarge and cause the walls of the ventricles (usually the left ventricle) to thicken. Primary cardiomyopathies 3.1.1 Genetic 3.1.1.1 Hypertrophic cardiomyopathy HCM is a condition of the heart in which a part of the myocardium or the muscle of the Interrelations of clinical manifestations, pathophysiology and therapy (2). N Engl J Med 1997336775-785. See our User Agreement and Privacy Policy. The Global Therapeutic Landscape of Hypertrophic Cardiomyopathy. A J Marian (Jan 1, p 58)1 postulates that cardiac contractility is decreased in hypertrophic cardiomyopathy (HCM) and that the preserved or increased ejection fraction observed in patients with HCM is a result of the concentric nature of the hypertrophy. In: Kodama K, Haze, K, Hon M, editors. Case17 years old male professional basketball player with noknown past medical history collapses on the playing floorduring practice and subsequently arrests. Takotsubotype cardiomyopathy due to multivesselspasm. The parts of the heart most commonly affected are the interventricular septum and the ventricles. Atrial fibrillation (AF) is frequently associated with HCM with a reported prevalence of about 20% to 25%. Hypertrophic cardiomyopathy (HCM) is a disease in which the heart muscle (myocardium) becomes abnormally thick (hypertrophied). CARDIOMYOPATHY BY: RICHARD KAMINSKI DESCRIPTION OF DISEASE • Hypertrophic cardiomyopathy (HCM) occurs if heart muscle cells enlarge and cause the walls of the ventricles (usually the left ventricle) to thicken. - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. Introduction. The thickened heart muscle can make it harder for the heart to pump blood.Hypertrophic cardiomyopathy often goes undiagnosed because many people with the disease have few, if any, symptoms and can lead normal lives with no significant problems. HYPERTROPHIC. Cardiomyopathy is any structural and functional abnormality of the heart muscle unattributable to specific causes or disease processes such as coronary artery disease (CAD), congenital heart disease, or valvular disease. - Famous for being leading cause of sudden cardiac death in young athletes ... Enlarged septum narrows left ventricle outflow tract. However, in a small number of people wi… 22: Figure 1. PowerShow.com is a leading presentation/slideshow sharing website. What Causes Hypertrophic Cardiomyopathy? The report also covers the descriptive pharmacological action … Primary cardiomyopathies 3.1.1 Genetic 3.1.1.1 Hypertrophic cardiomyopathy HCM is a condition of the heart in … Sato H, TateishiH, Uchida T, et al. ... Cardiomyopathy Pathophysiology. Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. Dilated cardiomyopathy is the most common type of cardiomyopathy.Although most cases are idiopathic, a number of conditions (e.g., coronary artery disease, wet beriberi), infections … INTRODUCTION. Circulation. E. Acute myocarditis. Hypertrophic cardiomyopathy (HCM) is defined as a primary cardiac muscle hypertrophy of the left ventricle in the absence of other structural or functional abnormality. Cardiomyopathies are diseases of the muscle tissue of the heart.Types of cardiomyopathies include dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular cardiomyopathy. It's FREE! Change in stress leads to adaptations. Circulation. Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. Classification and Definitions of Cardiomyopathies 9 3.1. Causes of hypertrophic cardiomyopathy. Cardiomyopathies are diseases of the muscle tissue of the heart.Types of cardiomyopathies include dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular cardiomyopathy. The global Hypertrophic Cardiomyopathy (HCM) Therapeutics market explains the Hypertrophic Cardiomyopathy (HCM) Therapeutics market development trends, market size and large-scale industry situation to provide progressive approximation. 1996;94:850-56. - Myocyte 'disarray' 2/2 sarcomere mutations causes LV hypertrophy, usually with ... hypertrophic subaortic stenosis) and ASH (Asymmetric septal hypertrophy) are ... - Hypertrophic Cardiomyopathy Board Review Rami Khouzam, MD Hypertrophic Cardiomyopathy Definition: WHO: left and/or right ventricular hypertrophy, usually asymmetric ... Heart Muscle Disease (Cardiomyopathy) (1). Hypertrophic cardiomyopathy (HCM) is an intractable disease that causes heart failure mainly due to unexplained severe cardiac hypertrophy and diastolic dysfunction. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime. If so, share your PPT presentation slides online with PowerShow.com. Hypertrophic Obstructive Cardiomyopathy (Case Presentation). In the early stages of cardiomyopathy, there may be no symptoms at all. Clinical aspect of myocardial Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. the diagnosis, characterize the pathophysiology for the individual, and identify risk markers that may inform decisions regarding interventions ... *HCM indicates hypertrophic cardiomyopathy . Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. MAIN TYPES OF CARDIOMYOPATHY Hypertrophic Cardiomyopathy: Hypertrophy means ‘increase in size.’ It is the increase in size of the heart muscle. Caused by blockages in coronary arteries ... Mimics myocardial infarction ... Alpha and beta blockers the best treatment. Five patients, all women, age ranges 59 to 84 years, with underlying hypertrophic obstructive cardiomyopathy (HOCM) presented with profound hypotension. 2,3 Recognised autosomal dominant mutations within sarcomere proteins are found in 55 % of adolescents with sporadic HCM. A J Marian (Jan 1, p 58)1 postulates that cardiac contractility is decreased in hypertrophic cardiomyopathy (HCM) and that the preserved or increased ejection fraction observed in patients with HCM is a result of the concentric nature of the hypertrophy. Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course, for which several disease-causing mutations in genes encoding proteins of the sarcomere have been reported.1–7 Because of the characteristic clinical, morphological, and genetic diversity, HCM has held the curiosity … Cardiac hypertrophy is usually asymmetrical with greatest involvement most commonly of the basal interventricular septum subjacent to the aortic valve. Heart 2010; 96(20):1669-75 [8] Richard P, Charron P, ... | PowerPoint PPT presentation | free to view, Global Hypertrophic Cardiomyopathy (HCM) Therapeutics Market Insight and Forecast to 2026. HCM can run in families, but the condition may also be acquired as a part of aging or high blood pressure. Summary. The two patients thought to be in cardiogenic shock were given inotropes … Introduction. Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder, affecting one of every 500 adults.It is found across all racial groups and is the most common cause of sudden death in young athletes ().The disease is characterized by left ventricular (LV) hypertrophy in the absence of another systemic or cardiac disease to account for the changes noted. Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course, for which several disease-causing mutations in genes encoding proteins of the sarcomere have been reported.1–7 Because of the characteristic clinical, morphological, and genetic diversity, HCM has held the curiosity … Powerpoint slides. Genetic Etiology of Hypertrophic Cardiomyopathy (HCM) ~30-60% of HCM patients have an identifiable pathogenic or likely-pathogenic genetic variant Many others have no genetic evidence of disease and / or The main pathophysiology behind is that every organ is in homeostasis with physiological stress. N Engl J Med. - The report provides comprehensive information on the therapeutics under development for Hypertrophic Cardiomyopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. ... An 80-year-old African-American woman is admitted to the hospital under your ... - Hypertrophic Cardiomyopathy Board Review Rami Khouzam, MD ... Congestive dilated cardiomyopathy. 14. Hypertrophic cardiomyopathy is inherited as an autosomal dominant trait and is attributed to mutations in one of a number of genes that encode for one of the sarcomere proteins including beta-cardiac myosin heavy chain (the first gene identified), cardiac actin, cardiac troponin T, alpha-tropomyosin, cardiac troponin I, cardiac myosin-binding protein C, and the myosin light chains. In other instances, the cause is unknown. Up to 60% of the cases are due to mutations in What Causes Hypertrophic Cardiomyopathy? Genetic Etiology of Hypertrophic Cardiomyopathy (HCM) ~30-60% of HCM patients have an identifiable pathogenic or likely-pathogenic genetic variant Many others have no genetic evidence of disease and / or Additionally, the report provides an overview of key players involved in therapeutic development for Hypertrophic Cardiomyopathy and features dormant and discontinued projects. Powerpoint slides. INTRODUCTION. 16. 1. Adapted from Spirito, P. et al. Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease affecting 1 of every 500 persons (1, 2).Individuals with HCM are at an increased risk of heart failure and sudden cardiac death ().Usually, HCM is characterized by cardiac hypertrophy with preserved or increased ejection fraction (EF) and cardiac contractility in the absence of secondary causes. However, the penetrance and expression of responsible genes vary, with complex presentations and sequela. It mainly manifests as symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle unexplained by other cardiac or systemic causes of hypertrophy (see Table 23–1 for differential diagnosis of LVH). Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. Aetiology. Retrospective trial by a group at the Mayo Clinic Aim: Long-term effects of myectomy on survival Looked at mortality retrospectively among 3 groups from 1983-2001: 1) myectomy 2) LVOT obstruction w/o surgery 3) Non-obstructive HCM Mean follow-up: 6 yrs Compared to non-operative obstructive, myectomy patients had superior survival free from all-cause mortality / HCM-related mortality / sudden cardiac death. Initial clinical and hemodynamic evaluation suggested cardiogenic shock in two cases, acute myocardial ischemia in two cases, and hypovolemia in one case. CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. Do you have PowerPoint slides to share? These proteins, namely beta-myosin heavy chain, myosin-binding protein C and cardiac troponin C, are structurally important in cardiac muscle. Hypertrophic cardiomyopathy. Cardiomyopathy is any structural and functional abnormality of the heart muscle unattributable to specific causes or disease processes such as coronary artery disease (CAD), congenital heart disease, or valvular disease. Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder, affecting one of every 500 adults.It is found across all racial groups and is the most common cause of sudden death in young athletes ().The disease is characterized by left ventricular (LV) hypertrophy in the absence of another systemic or cardiac disease to account for the changes noted. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, representing a leading cause of sudden cardiac death in the young and a prevalent cause of heart failure and stroke. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, representing a leading cause of sudden cardiac death in the young and a prevalent cause of heart failure and stroke. - Myocardial Infarction. HCM can run in families, but the condition may also be acquired as a part of aging or high blood pressure. Colors correspond to the Class of Recommendation Looks like you’ve clipped this slide to already. It mainly manifests as symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle unexplained by other cardiac or systemic causes of hypertrophy (see Table 23–1 for differential diagnosis of LVH). Hypertrophic cardiomyopathy is a primarily genetic condition affecting the sarcomeric proteins. Hypertrophic Cardiomyopathy Dr. Fuad Farooq Resident CardiologyAga Khan University Hospital. Classification and Definitions of Cardiomyopathies 9 3.1. Introduction. The disease has complex symptomatology and potentially devastating consequences for … This results in the heart being less able to pump blood effectively and also may cause electrical conduction problems.. People who have HCM may have a range of symptoms. N Engl J Med 1997336775-785 gt 140. Hypertrophic cardiomyopathy Characterised by myocardial hypertrophy,abnormal diastolic filling,intermittent ventricular outflow obstruction Related to defects in force generation owing to altered sarcomeric function Leading cause of LVH,unexplained by other clinical/pathologic cause Caused by mutation of genes encoding sarcomeric proteins Over the years, classification of this condition has been updated by the rapid advancement of genetic, imaging, and clinical investigation. XXX:XX-XX. In 2010, the Study Group on peripartum cardiomyopathy of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) defined PPCM as an idiopathic cardiomyopathy occurring towards the end of pregnancy or in the months following delivery, abortion or miscarriage, without other causes for heart failure, and with a left ventricular (LV) ejection fraction (EF) < 45% 5 (see Box). Etiology of Hypertrophic Cardiomyopathy is mostly due to: - 1. Aetiology. DISCUSSION: Hypertrophic cardiomyopathy(HCM) is a condition of the heart characterized by the thickening of the interventricular septum. In 2010, the Study Group on peripartum cardiomyopathy of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) defined PPCM as an idiopathic cardiomyopathy occurring towards the end of pregnancy or in the months following delivery, abortion or miscarriage, without other causes for heart failure, and with a left ventricular (LV) ejection fraction (EF) < 45% 5 (see Box). The ventricle size often remains normal, but the thickening may block blood flow out of the ventricle. Hypertrophic cardiomyopathy. Sudden cardiac death due to HCM-related causes is most prevalent in young African-American male athletes. See our Privacy Policy and User Agreement for details. It is occasionally restricted to other myocardial regions, such as the apex, the midportion, and the posterior wall of the left ventricle… Hypertrophic Non-Obstructive Cardiomyopathy (HNCM) is a subtype of hypertrophic cardiomyopathy, which is a condition affecting the heart muscle The term “hypertrophic” means enlargement of cells, which, in this condition, leads to a thickening of the heart muscle. Now customize the name of a clipboard to store your clips. Takotsubotype cardiomyopathy due to multivesselspasm. the diagnosis, characterize the pathophysiology for the individual, and identify risk markers that may inform decisions regarding interventions ... *HCM indicates hypertrophic cardiomyopathy . Hypertrophic cardiomyopathy (36%) Aortic stenosis 4% Congenital coronary anomalies (19%) Mildly increased cardiac mass (10%) Ruptured aorta … They are all artistically enhanced with visually stunning color, shadow and lighting effects. Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes which encode components of the contractile apparatus of the heart. In: Kodama K, Haze, K, Hon M, editors. D. Aortic stenosis. Complete heart block: 30-40% in early studies, now <10% using smaller doses of alcohol more selectively Large MIs: from alcohol leakage into other coronary arteries, Non-randomized study – aim to determine outcomes in a tertiary referral center Of 601 patients referred between 1998-2006, 138 chose alcohol septal ablation Median age 64 yo Fewer procedural complications in patients w/ myectomy: combined post-procedural complication rate 26% in ablation vs. 5% in myectomy 2 deaths – 1 patient transferred from OSH w/ cardiogenic shock, 1 patient w/ pulmonary HTN Overall survival: 93.5% at 2 yrs, 88% at 4 yrs, Initial registry study in 2000 looking at the efficacy of ICDs for the prevention of SCD in HCM patients Retrospective multicenter study of 19 centers in US and Italy 128 consecutive patients enrolled; ICDs placed between 1984-1998 85 pts = primary prevention 43 pts = secondary prevention. 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